Transcranial direct current stimulation and cognitive-behavioral therapy: Evidence of a synergistic effect in treatment-resistant depression

di Giordano D’Urso

Functional Area of Psychiatry, Department of Neuroscience and Behavior, AOU “Federico II”, via Pansini n. 5, Naples, ItalySchool of Cognitive Psychotherapy, Casa di Cura Villa Camaldoli, Via Antonio Cinque n. 93/95, Naples, Italy 

Dear Editor:

Although antidepressant medications and cognitive-behavioral therapy (CBT), alone or in combination, are considered effective treatments for depression [1], up to 30% of patients show no improvement or only a partial response [2]. Preliminary data support the efficacy and good tolerability of transcranial direct current stimulation (tDCS) in the acute treatment of patients with treatment-resistant depression (TRD) [3]. So far, however, no study has assessed the acute and long-term effect of combining tDCS and CBT in treatment-resistant depression… 2012_D’Urso et. al

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